When I first started I thought that leveling had to be perfect every time. I quickly realized that it doesn't matter that much. The smaller the item you are printing the less important it is.
I agree with Gr5, I don't touch the bed level for months and don't bother changing between nozzles.
It shouldn't scratch the glass unless its a big difference as the pressure of the plastic pushing out should help push the glass down enough and not scratch. I did it once by accident and there are no scratches but cant guarantee yours wont scratch.
When using the 0.25mm nozzle you normally wouldn't print a large item, just something small. So as an example if the bed is out 0.1 from back to front then over the tiny print surface in the middle it might only be out 0.01
I have the first layer at 0.05mm for that nozzle so that's plenty of room to flatten out.
On larger nozzles, yes they will normally be on bigger prints that would cover more area and could be out the whole 0.1mm, but your first layer will also be thicker so it still doesn't matter that much as long as it has enough squish to make it stick.