Thank you for your good questions.
To reduce the load on the extruder, print hole is not round, but in the form of droplets to remove air from the hole. Select the optimum depth of the holes and fill them 3/4. I think the depth does not exceed 1.5 mm. If the hole 10 layers of which remained not filled with 2 layers bottom and one from above, the neighboring hole will start from the layer 4 and the spike will start from the layer 6. So, do not necessary to know the exact volume of the hole.