Thank you all for the replies. I already used S3D with a leapfrog printer and would love to use it with my Ultimaker 2+ also.
What I understand now: I have to remove the first line in the Starting Script and tweak the movement speeds. Is the build space any different then the U2? Anything else I have to take care of?
Would be awesome if someone who uses S3D with a U2+ could share his fff file. This would be a great start for further tweaking.
Thanks you all for your replies.