Thank you Nicolinux,
I have thoroughly cleaned and re-greased the z-screw, it is running smoothly.
Whilst I was doing this I noticed that there is a lot of 'play' in the x-axis, each time the machine moves from left to right and back the whole bar connected to the motor that carries the print head pops in and out a few mm. I have tried lubricating the support bars too (with oil as instructed, not grease) but this hasn't improved things much, am I missing a washer or some sort of spacer to stop this movement? I didn't assemble this machine, it arrived pre-assembled in the box.