I have been suffering badly with the extruder insisting on traveling to either the front or the left edge, I cured this by turning the brim off.
I then started to suffer with the print getting about half of the bottom level done before it decided to have a hissy fit in the extruder stepper motor.
It insisted on winding the PLA in,out,in,out of the extruder this resulted in the PLA getting a lump on the end in the extruder but out of the screw tube. I had to stop the print and clean the extruder every time, this meant totally reseting the bed every time as I had to unscrew the extruder from its mount.
After a day of this I tried again with the first item I had printed (not sliced with CURA) and it work perfectly.
I used Repetier host to slicer the item I had been having problems with (this uses an old version of CURA) and, would you believe it, a perfect print. The new CURA slicer is not working for the Anet A*.