Same here, Chuwi Lapbook Air, Win10Pro 1903, latest drivers from Intel installed.
For 4.0 and 4.1 releases, I always needed to set compatibility mode to get Cura started. Now, compatibility mode shows icon on taskbar, I see in task manager, cura.exe occupiig memory continuously up to 100MB at 25% CPU load, suddently memory dropping to 32kB and then cura.exe terminating.
Same in normal mode, but here, as with 4.x before, it occopies memory up to 75MB and stops responding, no GUI or icon shown.
Windows log shows exactly the same as arkanjo wrote, related to _ssl.pyd