This is probably not helpful, but installing 4.7.1 and printing, just worked fine.
Before printing, I did go in and confirm that the "machine" settings didn't change.
They were fine.
I only mention this, because with older versions, including 4.3, which I was using all along, would screw up the odd time and do some weird things. Even without changing profiles.
What I discovered is that for some odd reason, Cura would corrupt or change some settings in the printer profile (machine).
Most often, it would change my 1.75 filament size to the larger s