Yep....me too and with 4.21 also show this behavior.
But, I found a "cure", and if i copy all dlls from a fresh copy of CURA and overwrite the files in the install directory the program is able to start again without reinstalling anything and with all features working normally.
But then, I close the program and it won't star again.
That keep me thinking if there is an issue with windows 10.....blocking some of the dll's....
best regards...