Same problem here: just upgraded to 4.4.1 from 4.3.0 on prompting from Cura, to find it crashes at every startup, even when run as administrator. "Upgrade" removed old version - I said "yes" to remove all config files, so effectively a clean install.
Win10 Home x64 18362.535 Version 1903. Core i7 4790 + 16GB
Anycubic I3 Mega but not cabled.
one crash report submitted, have now fully uninstalled and reverted to 4.3, so no longer have any logs. Could recreate I guess.
Let me know if you want any other information.