Same problem for me, only all the time not just after a windows restart. Cura worked great for about 2 weeks then started asking for setup again at nearly every launch. I've just started opening a half dozen instances of cura back-to-back and usually at least 1 of them will open the way it should, without asking to go through setup again. It's a ridiculous workaround, but it seems to work. Hopefully with the next update you can address this issue!