@Miech this solution doesn´t work for me :-(
i have a brand new computer now... new processor new ram new mainboard new SSD ... only the gtx 1080 stayed and my two monitors...
i have a brand new ssd and new windows 64 bit pro installed
and still on this fresh installation cura 4.5 isn´t starting ... so it must have problems with nvidia / two monitor setup but like i said miech´s solution isn´´t fixing it for me :-(