Hi,
I know this is an old post, but I had simular issues. Because I spent a lot of time searching for a solution, and I used a lot of filament, I hope you do not need to go thru the same learning curve.
I drew the same object all over again I use Sketchup) , and the first print was perfect (cura 3.2.1)
I have a Anet A8 pro. I tried 3 versions of Cura 14.7 (old stuff, included with the printer), Cura 3.2.1, and Cura 4.5. All gave the same problem. In the 2 last versions, I tried everthing which is mentioned in this post. I also tried flipping the object and tried other ways of creating the STL file. Sometimes it was slightly better: fe. flow rate at 103%, ironing with 15% flow, skin overlap percentage and infill overlap percentage at 100%,... gave some improvement. (But you know this is not the way it should...). in the mean time, I printed more then 20 discs (with holes in it - which gave the problem).
I checked my model (skp) inside, outside, everything I could do, but did not found anything special.
So I started from scratch, drew everything again, and first time right.
(I thought I read that also somewhere higher in this post)
Succes.
Karl