So, Ultimaker Cura claims to "integrate with CAD software for an easier workflow". Hmm, they cannot integrate the support of 3DConnexion driver in almost a decade 😄 Ahhh yes, there's the plugin... Well, it stops working with every Cura update. PrusaSlicer does it right out of the box, no fiddling with plugins. I know it, because I tried 😉 Even FreeCAD, the open-source 3D CAD developed by community, does support 3D mouse (through alternative linux drivers). But Ultimaker sticks to 2D mouse and UI control from 90's.
Btw. the first commercially available 3D mouse (Magellan) was available in 1993 and you can still buy them at ebay as vintage. So, 3D mouse has 30-year anniversary in the next year. 🙂