Hi fvrmr, I think you're onto something! Following on from your question, I opened Cura using just the native laptop monitor (without the two external monitors), and Cura behaved perfectly. I could select and rotate objects on the build plate that incidentally opened in the centre of the window. I connected up my other two monitors and found that I could move the Cura window between monitors, but only the laptop monitor allowed correct operation, the other two external monitors would not allow me to select/rotate objects. Also, if I move the Cura window from the laptop monitor with the object centred, to another monitor, the build plate moves to be largely off the screen. It really is that simple. I can switch from a working Cura to a failing Cura just by moving the window between monitors. Obviously, it's a bit clunky, but I'm now out of jail.
Does his help you work out what is going on and develop a fix?