I think I have it solved, found this on Github. I have a Dell laptop and it had Dell backup and Restore from new, uninstalled it and now Cura is working fine. Thanks for the help.
"NOTE: If you have a Dell Laptop/PC, this may be useful information or something to at least look at trying. We had this same crash issue when opening/saving files on my wife's Dell laptop with Cura ver. 4.1.0 and even the latest 4.2.1 -- see Cura Git issue #4220 for more specific details.
The issue was fixed after disabling 3 Dell Backup & Restore Shell Extension services (used Nirsoft's shexview.exe). Here are 2 of 3 disabled:
DBROverlayIconBackuped.DBROverlayIconBackuped
and
DBROverlayIconNotBackuped.DBROverlayIconNotBackuped
The third (disabling may not have been needed) but it was named something very similarly and likely related, so I went ahead and disabled it as well."