Most tweaking with settings is about changing the print quality from good to awesome.
The biggest problem I see, on the forums, groups and in person, is that people have mechanical issues (wrong assembly) and try to fix that the wrong way, with setting changes for example.
I was a bit worried about that too
But the great thing is, after I put the Ultimaker together, I have a pretty good idea how it works, and can adjust if needed.
The software (Cura) runs very good after install, and I get great prints without tinkering with the software,
and you can make adjustments, if you see certain prints have not the desired effect.
you will have to put a bit of time into it, t get the hang of all the stuff, but the more time you put in the better the prints get
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