I have the same problem. I am also using v. 4.2.1 (Windows 10) but the problem was the same in older version (see https://github.com/Ultimaker/Cura/issues/4162)
I discovered that when I save a profile it is saved all right in C:\Users\My Name\AppData\Roaming\cura\4.2\quality_changes but when I open Cura it is read just in C:\Users\My Name\AppData\Roaming\cura\4.2\quality
I solved myself manually editing profiles in files in \quality folder but is not the right solution.
I include my configuration files:
Edited by RobyRob
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jens3 11
This may be related to the problem I reported in this thread here:
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