Poor Print Quality Cause?

[jmaxwell14 0]

My company purchased an Ultimaker S5 for a job and we have been printing parts consistently for a few months now with the same print profile. All of a sudden, prints are beginning to be super inconsistent and most commonly coming out like the picture below. It is very important to resolve this issue as soon as possible as the deadline for the project closes in and we are falling behind on print time. 

 

I have tried doing (tons) of hot and cold pulls on the print cores. I have also switched the print cores out with replacements and run into the same issue. We currently have a new set of print cores on order and I am hoping this will resolve the issue, but in the meantime, what are your guys thoughts on what causes issues like this?

Using Tough PLA with AA 0.4 and PVA with BB 0.4. Infill on 20%, printing at 215*C,  print speed is 100mm/s, layer height of 0.25 mm.