For layers with hatch like infil, combing is no big deal and usually saves time because you skip a retraction step. But for bottom and top layers combing can make an ugly scar. So for example if you are printing a cell phone case where you want the bottom layer to be the best layer, then you probably won't combing off. For 90% of my prints I have combing on.
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IRobertI 521
Stated in another way it tries to avoid crossing over perimeters of the part so that travel moves are performed over infill to avoid defects on the outside surface.
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