I use both Simplify 3D and Cura
I have been using Cura for about 5 years, perhaps more, and I am still very confused by the way the profiles (or materials) works in Cura
It is not clear at all how to create or adapt materials settings, and then when it asks whether you want to keep or discard changes to the print settings, again it is also not clear what it is asking - it is confusing
I have been desperate for a tutorial video on how to do this
There is a video from a few years ago but this still does not cover it properly
Many times I have fine-tuned the settings for a particular printer, then lost these settings because I did the wrong thing at the question save or discard changes
Nowadays I keep a spreadsheet with all my preferred materials settings so if I lose them in Cura, I can reinsert them manually, but this is very time consuming
With Simplify3D it is much easier to create and edit materials for your printer
I think a lot of users probably use very standard materials and so don't need to do a lot of fine tuning - I use materials such as ninjaflex that are difficult to get right so I have to do a lot of fine tuning which is difficult in Cura but easy in Simplify 3D
I am a professional user but I still have problems - so I suggest something is wrong
Peter