This occurred all of a sudden, I'm getting an "internal server error" from Cura, when trying to upload gcode, it also fails when I try to upload a saved file to octoprint directly, so it doesn't seem to be an issue with Cura communicating with the server, and a test with same stl's sliced in slicer uploads/prints fine. The only change is a switch to a larger nozzle, but the problem doesn't seem to be the printer or octoprint, as both are functioning normally.
I have a feeling it's something in Cura's configuration, but can't figure it out. If anyone has any advice, that would great.