I've been using the the Generic PLA profile, and that seems to work just fine.
However, I purchased some eSUN PLA+ and decided to use the installed profile, but when I did that the slicing profiles all disappeared (even the default ones) leaving me with 'unsupported profile'.
When I switched back to the Generic PLA, the slicing profiles came back.
I was able to Duplicate the Generic PLA material profile, but as soon as I set the manufacturer to 'eSUN' (or anything else for that matter) the slicing profiles disappeared again.
Pretty sure this is not planned behavior. I have uninstalled, cleaned up the Cura 5 profiles folder in the roaming and local profiles, and the reinstalled using the download of the stable release from this morning, and am seeing the same issue.