I am having a similar issue with CUra. I even upgraded to 5.3. I either get a a Full, BSOD crash or Cura generates a "You should send a bug report" message on the screen. All I'm trying to do is slice a file. Bug report sent. I loaded PRUSA slicer and clioced the same file without issue. The minute I try it with CURA I get the bug message. After a reboot... like immediately after, when I slice the same file, I get a BSOD and the machine restarts.
This was amy gaming rig, and yes, it as a Asus ROG mainboard/ AMD CPU