Was there ever a resolution to this issue? I'm on Cura 4.13 and had no issues last night using my laptop, mouse and laptop screen. Today at work, I cannot select the model with the Left click, and none of the handles for rotation, movement, etc are selectable via mouse. Searching for this issue lead me here.
However, when I dragged Cura off one of my external screens (third monitor on the left) to the laptop screen (first monitor on the right), all selections and the mouse button were working as expected.
Seems to me, it only affected me when on my external monitors. Perhaps cura has a hard time determining where the mouse is when it's not on the primary monitor.