This report reminds me of https://github.com/Ultimaker/Cura/issues/15179
Can you try the following:
1. Turn off "Generate Support".
2. Go to the Mesh Fixes settings and turn off "Remove Empty First Layers".
3. Turn on "Generate Support"
I believe it's resolved with the next release with this fix: https://github.com/Ultimaker/CuraEngine/commit/3b1f2e612534f0ed05e022159a5308a6d2c30479
I floated models by CAD before, too. I can lift them now when I turn off " Automatically drop models to the build plate" switch by setting of Cura.
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