The main thing for a good STL is the xray check. If you see no red then the model is pretty good and unchecking all the fix horribles should give you a good result.
Also try not to let polygons be smaller than .1mm.
Cura slices the polygons into a layer and gets a set of lines in no particular order (stl doesn't say which polygons are connected) so then cura strings the lines up into loops. Sometimes two unrelated loops have a point too close together. I've seen this a lot. Cura picks the wrong point and it comes out all wrong. This only happens when you have lots of details much too small to print.
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gr5 2,224
Try unchecking all the "fix horrible" checkboxes. "type A" is probably checked and is probably filling your hole.
They are in the expert menu.
The problem probably relates to "surface normals" which tell cura which side of a polygon faces air and which side faces interior.
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