Jump to content
Ultimaker Community of 3D Printing Experts
faalexand

ABS Biocompatibility

Recommended Posts

Has anyone looked at the Biocompatibility of the ABS filament supplied by Ultimaker? I'm printing some parts that will make contact with human cell lines in culture and wanted to know if the materials are cytotoxic.

Share this post


Link to post
Share on other sites

http://www.ncbi.nlm.nih.gov/m/pubmed/16179758/?i=1&from=Acrylonitrile%20butadiene%20styrene%20cell%20culture

Making a new ear?

I would be a little worried about what could leak out of the plastic during cell culture that might affect the cells even if it is not cytotoxic. Natural PLA might be safer considering it is not made from oil but who knows. Please let us know when you have tested it. Maybe ultimaker could sponsor 6 microarray assays...

Share this post


Link to post
Share on other sites

Not really. Antibiotics are usually added to the culture media and you really don't want any possible adverse effects from the unknown antibacterials added to the filament. The best filament to use should be completely biological inert or alternatively just support the attachment of the cells to the plastic.

Share this post


Link to post
Share on other sites

ABS is usually not cytotoxic. BUT: cytotoxicity depends not only on the material, it depends also on processing conditions and contact liquids used in an application. To high processing temperatures (> 260°C) will result in decomposition products (e.g. Styrene) and solvents could extract traces of potential byproducts (e.g. Butadiene).

Share this post


Link to post
Share on other sites

Quick update to this topic if anyone was wondering. I ran a quick biocompatibility check with some of the material according to ISO 10993 and it didn't seem to have any adverse effects on L929 murine fibroblast cells.

  • Like 1

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Announcements

  • Our picks

    • Architect Design Contest | Vehicles.
      We're open for entries! - Design and submit your 3D designs of architectural entourage - vehicles - for a chance to win a large filament pack. Presenting an idea, an architectural design or something as big as an urban project isn't easy. A scaled model can really help to get your idea across.
        • Like
      • 25 replies
    • What The DfAM?
      I'm Steve Cox, an experienced engineer familiar with 3D printing. I wanted to share some DfAM guidelines with this community to help and make stronger parts.
      I'm also an Autodesk Certified Instructor for Fusion 360, so many of the images in ...
        • Thanks
        • Like
      • 23 replies
×

Important Information

Welcome to the Ultimaker Community of 3D printing experts. Visit the following links to read more about our Terms of Use or our Privacy Policy. Thank you!