Don't cut holes in them, they are too nice looking for that
If you want to, you could get some laser cut acrylic sheets and fit those instead... it should be very easy to find the drawings for the frame of the machine on GitHub (they are open source by now), modify them to your liking (draw a cutout in the centre of the side panels) and send the drawings off to a laser cutting service to have them made in 6mm. acryliic.
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Labern 775
The sides are what holds your printer together. Do not remove them.
You could cut out holes to be more like a UMO if you really wanted.
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