I've recently found a bug with some profile writing that could cause the corruption (i'm not a 100% sure if I fixed it, since it happend once every few thousand saves, so it's hard to validate it). This should be fixed for 4.7
Other than that, you can enable backups in extensions -> cura backup
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Nexnex77 0
I found a 2 month old Zip file in the config folder and copied it over, i got nearly all my settings and materials back. Still i do not know what happend but now i know what to backup in case it happens again...
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