I have a few thoughts. First of 100 pounds is - wow - a very heavy plane. Where are you going to store and build such a thing? I guess a garage because you will probably need a big door.
Anyway, stay away from CF (carbon fill) filaments as they are no stronger and no more stiff (and stiff is bad for filaments usually). Nylon is amazingly strong due to it's flexibility but not my favorite material for quadcopters because it's a bit too flexible. Still it's amazing - you can drive a car over pretty much anything made with nylon and it will flatten but bounce back to it's original shape.
Really I would stick with PLA for the strength as it's hard to beat. But I would mix it with CF rods that you can buy from places that sell RC kits. Those rods are really amazing and you can integrate them into your designs. For example when making the fuselage have many rods running the length of your fuselage such that they somehow attach or latch onto the PLA fuselage. You can use the CF rods for cross bracing as well.
Really it's hard to beat balsa wood (coated with soemthing to add strength) when it comes to light weight and strong.
As far as "injection mold" smooth - you could use PLA/PHA and completely submerge in acetone. There's a lot of discussion including helpful videos in this topic:
https://ultimaker.com/en/community/10412-acetone-finishing-on-pla
Or you can go the ABS route which is easier to process with acetone but ABS you will probably find has horrible layer adhesion unless you enclose your printer and turn the fan almost completely off. It takes a while to learn a new material. ABS is excellent for aircraft - it's a tiny bit more flexible than PLA (but same strength) and that tiny increase in flexibility means it is much much less brittle (think crashes).
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Kevparang 10
My printer temperature can go to 290C hotend and 90C heated bed. It is glass.
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