Ok, let me try and give you a sequence of operations to reproduce the behaviour:
Load Cura 4.2.1 on Ubuntu computer .... sorry for the long post that follows:
Cura is configured for two different printers with one being a single extruder printer and one being a dual extruder printer
I start Cura
Cura starts (in this example) with the dual extruder printer active and the 'print settings' dialog open
I change the layer height figure, the profile shows a star indicating an unsaved condition, I click on the star, I get the 'preferences' dialog , profiles sub dialog and I select 'update profile with current settings/overrides. The dialog indicates that the settings are saved (by graying out) and I close the 'preferences' dialog.
I close Cura
I open Cura again and verify that yes, the print settings dialog shows the changed layer height.
BTW, Cura reports configuration errors with several profiles named 'creality_cr-10_empty, empty #2, #4 and #5 and asks me if I want to throw out all my configured profiles and printers. I dismiss the warning without resetting anything.
I now switch the active printer from the current dual extruder version to a single extruder version.(creality cr10)
Cura ponders life over this for a rather lengthy time and then shows the new selected printer.
Again, the print settings dialog is open (but not on the custom profile that was last active but on the 'extra fine' canned profile
I update the profile to one of my custom profiles, set layer height, update the profile, save the changes and Cura thinks it has saved the changes.
I close Cura
I open Cura
I again get a message of configuration errors but this time the errors are for the creality cr 10 empty #2, #4,#6, #7 and #5 profiles (note that Cura is creating these empty profiles every time the creality printer is selected)
The print settings dialog that opens up by default is one of the 'empty' profiles and not the profile that was last used.
I select the profile that was last used but the layer height is not what was previously saved (it appears to be the settings of the 'empty' profile)
.... and there we are .... hopefully that explains things.
No actual models were loaded at any time.
Let me know if you you want any log files (and let me know where to find them on a Linux box running Ubuntu)
BTW, I didn't want to post this long song and dance if this was a known problem which is why I started with a minimum of information first.Edited by jens3
Issues about cura are best raised at https://github.com/Ultimaker/Cura/issues/new/choose
That being said; we will need a lot more information in order to resolve your issue. So try to provide reproduction steps and logs
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