Ender5! I've seen this with Ultimaker 2 printers sometimes. It's the same reason. I've explained the problem in careful detail but the quick summary is that it is flipping bits. So is this an SD card or a USB cable print? The problem is that the printer is occasionally reading one bad bit in the gcode and it does large movements and what you describe is exactly the most common symptom (there are other symptoms).
So if you have an SD card reader then take that apart and clean it very well. Also clean the SD card and maybe try a different card.
If instead you print through USB cable then try a different cable or more importatnly try a different computer or different port on that computer.
Another potential fix is that many printers have ribbon cables that connect USB and/or SD card to the main computer. Try re-routing those (even moving just a few mm might help) to avoid "signal cross talk".
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@Christian_Kirk did you ever solve this? This popped up awhile back for me too. (Marlin FW, custom everything).
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