Cura is a great slicer but not really great at printing through USB.
I recommend using different software. I really like prontrface (aka printrun) which you can find here. Or use an SD card if your printer accepts that as SD card is 100X more reliable than printing through USB.
But to truly, actually answer your question, you need to supply what type of operating system you are using as the answer is very different for ubuntu, mac, windows and what version of that operating system. Maybe google around about how to get the serial comm port working for a 3d printer (for your particular operating system). My guess is that you can't get it to work with Cura on Windows as Cura uses only low numbered com ports (like COM3 or COM4) but lately windows seems to like numbers around COM12. Whereas prontrface and other's don't seem to have this issue.
Same situation here...
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