Not sure of any other issues it might bring.
An issue I've heard in the one of the forums here is that when the head approaches the center, it is a shorter distance to the extruder drive so the bowden will have to bend in one direction or another. This bending and straightening could cause a push of the filament. I haven't heard of anyone trying it yet though to find out for sure.
i've thought of doing the same, one of those things on the list that seem to be minor improvements with lots of work. As a short term thing I did because of a now shortened bowden tube is move it to the center of the machine with a part I printed in soft PLA, not a big difference but helpful. It also has the added benefit of removing the humming noise that reverberates throughout the frame from the motor. I think the 'sitting above' approach might help as you said, just that the envelope of the whole machine is much larger. Not sure of any other issues it might bring.
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