Not sure of any other issues it might bring.
An issue I've heard in the one of the forums here is that when the head approaches the center, it is a shorter distance to the extruder drive so the bowden will have to bend in one direction or another. This bending and straightening could cause a push of the filament. I haven't heard of anyone trying it yet though to find out for sure.
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fluxline 0
i've thought of doing the same, one of those things on the list that seem to be minor improvements with lots of work. As a short term thing I did because of a now shortened bowden tube is move it to the center of the machine with a part I printed in soft PLA, not a big difference but helpful. It also has the added benefit of removing the humming noise that reverberates throughout the frame from the motor. I think the 'sitting above' approach might help as you said, just that the envelope of the whole machine is much larger. Not sure of any other issues it might bring.
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