Well, so "printing direction" means... "Z direction".
I'm not sure why did you make this choice of positioning the part (looks like part of an enclosure with ventilation holes, but is just an impression). The point here is that the piece seems to be longer in the "print direction", which makes it somehow fragile.
This being said, the area between the holes is perhaps 5 mm or so. 50 mm/s is too much for such short perimeters. At the corners, the nozzle will drag the extrusion a bit in the new direction so that it will not be laid straight. Additional to the advice in the post above, just try to increase fan speed.
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prb4 6
You are printing quite fast and cold so I would guess it is under extrusion after the jump over the gap.
I would try either printing hotter (230 C),
or printing slower (20 mm/s)
or printing in thinner layers (0.1)
or a combination of these.
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