So the permission denied is a huge clue. Does that folder exist? Does that file exist? If so, try to delete it. Maybe there is a cura running that you can't see but is hanging onto that file. Check for a process named cura. If you *can* delete the file then it's probably not because some other process is running.
Could the disk be full? Make sure there is a GB of space or so available. A full disk would be one way to get this exact error.
Uninstall is not the best - better to delete that whole roaming/cura folder (while cura is not running) and then launch cura again (it will create that folder structure from scratch).
I've already uninstalled and reinstalled twice to no avail.
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