The S5 with its filament/flow sensor can detect when the spool is empty and pauses the print. But you should be aware, that when it stays in pause for several hours that you will see then some under extrusion on this layer. So try to keep the time as small as possible.
There is a postprocessing script available "Pause at Z" but I have read, it is currently not working in the S5, so this is currently not an option.
Filament spools are available from some brands in 1kg or 2kg, but as far as I know not in a Tough PLA comparable material. Often just PLA.
Using both heads is possible with some tricks, you have to split your model into 2 parts in your CAD software, import both in Cura, then assign Extruder 1 to one part and Extruder 2 to the other part and combine/merge the parts then together again.
I would try if the suggestions from @geert_2 could work for your model. Infill percentage is often too much and not needed, but depends on the model and your needs. I often print parts with just 10% or even less without any problems.
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geert_2 558
Maybe you could reduce infill, if that would be what uses most material? If you need a certain wall thickness for strenght, set the walls to way more than the usual 2x nozzle width, lets say 20x nozzle width (e.g. 8mm instead of 0.4mm). And leave the rest empty or sparsely filled (20...30%)? I don't know what you are going to print, but for tires for lightweigh toys, it *might* work? For a heavy equipment tire, it won't.
Or something along this line?
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